Click here to go straight to the most wanted page, the new classification of human transcription factors. It comprises now the majority of human TFs, altogether 1557 human TF genes, encoding more than 3200 proteins. The classification has been published in Nucleic Acids Research (Wingender et al., TFClass: An expandable hierarchical classification of human transcription factors. Nucleic Acids Res.2012, doi: 10.1093/nar/gks1123 (2012)).

September 22, 2014: The classification of murine transcription factors that have human orthologs has been finalized, including UniProt and TRANSFAC® links. It documents 1147 TF genes, enconding more than 1780 proteins.

July 27, 2014: For all human TFs including numerous new splice variants, the links to TRANSFAC and Protein Atlas have been updated.

July 14, 2014: For all human TF genes ("genus" level of the classification with five-digit classification numbers), mouse and rat orthologs were added. They were mainly retrieved from UniProt, manually double-checked for by human-mouse-rat alignments and occasionally identified or confirmed by additional BLAST searches.

February 23, 2013: Many transcription factors were linked to logo plots describing their DNA-binding specificity. They were constructed by Philip Stegmaier (my special thanks to him!) on the basis of the Positional Weight Matrix library recently published by the group of Jussi Taipale (Jolma et al., Cell 152, 327-339 (2013); PubMed 23332764).

The complete list of previous changes is here.