3.5 Class: Tryptophan cluster factors (WC)
Description: TRANSFAC® class description C0022: The tryptophan clusters comprise several tryptophan residues with a spacing of 12-21 amino acid residues; the subclass of myb-type DNA-binding domains typically exhibit a spacing of 19-21 amino acid residues. All IRF family members, except IRF-1 and IRF-2, contain conserved IAD, IRF association domain that is responsible for protein-protein interactions with other IRF family members or with Ets factor PU.1 and/or bHLH factor E47. IRF-1 and IRF-2 contain IAD2 that is conserved between them and, like IAD, involved in protein-protein interactions. (PMID 10586038)
Aligned domain sequences: Alignment of WC domains
Download fasta file Family 3.5.1: Myb/SANT domain factors
Download fasta file Family 3.5.2: Ets-related factors
Download fasta file Family 3.5.3: Interferon-regulatory factors
Logo plot: Note: The three families of this class do not share significant sequence similarities. Therefore, logo plots of their DNA-binding domains are given for the three families distinctly.
Family 3.5.1: Myb/SANT domain factors
(The gaps between positions 21 and 29 as well as between 49 and 61, which have been skipped from the logo shown, are due to long insertions in some of the aligned sequences, with very little conservation.)
Family 3.5.2: Ets-related factors
Family 3.5.3: Interferon-regulatory factors