| 3.3 | Class: Fork head / winged helix factors (FKH) | |
| Description: | TRANSFAC® class description C0023: Identified by homology between HNF-3A and fkh. The domain comprises approx. 110 AA. Analysis of the crystal structure has revealed a compact structure of three alpha-helices, the third alpha-helix being exposed towards the major groove of the DNA. The domain also exerts minor groove contacts. Upon binding to DNA, it induces a bend of 13 degree. | |
| Aligned domain sequences: | Alignment of FKH domains Download fasta file Family 3.3.1: FOX factors Download fasta file Family 3.3.2: E2F-related factors Download fasta file Family 3.3.3: RFX-related factors |
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| Logo plot: | Note: The three families of this class do not share significant sequence similarities. Therefore, logo plots of their DNA-binding domains are given for the three families distinctly. | |
| Family 3.3.1: FOX factors |  |
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| Family 3.3.2: E2F-related factors |  (The gap between positions 43 and 63, which has been skipped from the logo shown, is due to a large gap in most of the aligned sequences, and little conservation among the remaining ones.) |
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| Family 3.3.3: RFX-related factors |  |
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