2.2 Class: C4 zinc finger GATA factors (C4-GATA)
Description: TRANSFAC® class description C0004: Zinc finger motif of C4 type. Each finger comprises 4 cysteine residues presumably coordinating one zinc ion. TRANSFAC® class description C0003: Zinc finger motif of GATA-type. Can be subclassified into two sub-types, one of which is found in animal factors, the other one in plant factors. In fungi factors from both groups have been found. Most known animal GATA factors contain two zinc finger domains; most known fungal, plant and slime mold GATA factors only one (PMID 9581501). In case of the two-fingered factors, as far as it has been investigated, only the C-terminal zinc finger plus an adjacent basic region are essential and sufficient for DNA-binding (PMID 2276623, PMID 1406646, PMID 8446581). Each finger comprises 4 cysteine residues coordinating one zinc ion. The DNA-binding zinc finger is composed of two irregular antiparallel beta-sheets and an alpha-helix; similar in structure, although not in sequence to the zinc finger of the glucocorticoid receptor DNA binding domain. The alpha-helix and the loop connecting the two antiparallel beta-sheets interact with the major groove of the DNA. The basic region carboxyl-terminal to the zinc finger wraps around into the minor groove (PMID 8332909).
Aligned domain sequences: Alignment of C4-GATA domains
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